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"\n", " \n", "* **Triplet relationships**\n", "\n", " So far, we have looked at the relative timing of two spikes, $\\Delta t$ on the horizontal axis.\n", "\n", " Come up with a triplet spike protocol, that involves not just the time difference between two but between three spikes. Make a 3D plot of $\\Delta w$ as a function of the timing parameters $\\Delta t_1$ and $\\Delta t_2$. What do you expect to see?\n", "\n", "
\n", "\n", "* **Multiphasic windows**\n", " \n", " Patch clamping is a common recording technique that uses a micropipette filled with a liquid that mimics the intracellular environment. When cesium ions (Cs+) are introduced into this solution, an extra potentiation window is seen for long pre-after-post delays. This thought to be caused by cesium blocking of potassium channels, which depolarises the postsynaptic neuron, and enhance and lengthen backpropagating action potentials in the apical dendrite [I]_.\n", "\n", " \n", "
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